Optimized Reaction Conditions for Amide Bond Formation in DNA-Encoded Combinatorial Libraries
نویسندگان
چکیده
منابع مشابه
DNA-encoded chemical libraries.
The discovery and development of novel drugs for the multitude of targets originating from functional genomic research is a challenging task. While antibodies can nowadays be raised against virtually any given target using phage-display methodologies, a similar "selection/amplification" approach for the facile discovery of low-molecular weight compounds capable of specific binding to protein ta...
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Amongst the many ways of constructing the amide bond, there has been a growing interest in the use of metal-catalysed methods for preparing this important functional group. In this tutorial review, highlights of the recent literature have been presented covering the key areas where metal catalysts have been used in amide bond formation. Acids and esters have been used in coupling reactions with...
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Nanostructured RuO2 powders were synthesized via a hydrothermal method at 180 °C for 12 h using 1 and 2 M NaOH aqueous solutions. The structure of the obtained nanomaterials was investigated by powder X-ray diffraction (PXRD) technique. The morphology the obtained materials were studied by field emission scanning electron microscope (FESEM). The technique showed that with changing the reaction ...
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ژورنال
عنوان ژورنال: ACS Combinatorial Science
سال: 2016
ISSN: 2156-8952,2156-8944
DOI: 10.1021/acscombsci.6b00058